Opioid addiction affects millions of individuals and families across the United States, and many people need more than counseling or detox alone to achieve lasting recovery. Medication-Assisted Treatment (MAT) is one of the most studied and effective approaches for treating opioid use disorder, and new therapies like Brixadi® (extended-release buprenorphine) are expanding safe, stable, and long-term treatment options.
Brixadi® is an FDA-approved, extended-release buprenorphine injection designed to reduce cravings, prevent withdrawal, and stabilize recovery. It is available in both weekly and monthly formulations, allowing providers to tailor treatment based on a person’s stability and needs.
While Brooks Healing Center focuses on whole-person addiction treatment, we also support individuals who use MAT, including the buprenorphine-based medication Brixadi®, to promote long-term sobriety, safety, and wellness.
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| Treatment Component | Brixadi® |
|---|---|
| Active Medication | Buprenorphine extended-release |
| Used For | Moderate to severe opioid use disorder |
| Formulations | Weekly and monthly injections |
| Administration | Provider-administered injection |
| Treatment Support | Therapy and counseling, skills training, and relapse-prevention support |
| Individualized Planning | A licensed MAT provider determines eligibility, dosage, and timing. |
Brixadi® (buprenorphine extended-release) is a long-acting injectable medication used to treat moderate to severe opioid use disorder.
It works by:
Buprenorphine is the same core medication used in Suboxone®, Sublocade®, and other MAT therapies, but Brixadi® offers more flexible dosing and gradual release over days to weeks.
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The main advantage of Brixadi® is customizable treatment, allowing a smooth transition from early stabilization to long-term maintenance.
| Formulation | Use Case | Typical Benefit |
|---|---|---|
| Brixadi® Weekly | For people early in recovery or transitioning from other medications | Provides steady stabilization while reducing risk of relapse during early weeks |
| Brixadi® Monthly | For stable individuals who no longer need weekly injections | Supports long-term maintenance with fewer appointments |
MAT combines:
✔ FDA-approved medications
✔ Therapy and counseling
✔ Skills training
✔ Relapse-prevention support
Brixadi® fits into this model by:
Brixadi® may be appropriate for individuals who:
A licensed MAT provider determines eligibility, dosage, and timing.
Most are mild and resolve over time:
Serious reactions are rare but possible, including respiratory depression if combined with sedatives, benzodiazepines, or alcohol.
With no daily ups and downs like tablets or films, Brixadi® releases medication steadily.
Because it is an injection administered by a provider, it cannot be lost, stolen, or misused.
People often report feeling “normal” and emotionally stable during treatment.
Monthly doses can provide up to 30 days of stabilization.
Clients can fully engage in treatment without being distracted by cravings.
Brixadi is often chosen when a person wants flexibility, gradual stabilization, or an alternative to Sublocade.
No, while buprenorphine is an opioid medication, it does not produce the full euphoric effects of heroin, fentanyl, or painkillers. This medication is also given directly from a licensed provider, rather than taken home where it has potential for abuse. It is clinically proven to reduce addiction symptoms, prevent relapse, and support long-term recovery.
Brooks Healing Center provides clinically grounded, whole-person addiction treatment. We support clients who are using MAT, including buprenorphine therapies such as Brixadi®, while addressing the emotional, psychological, and trauma-related components of opioid addiction.
Our program includes:
Getting treatment with Brixadi® from our providers at Brooks isn’t the whole story, but it can be a powerful foundation for recovery when combined with therapy and compassionate care.
Coverage and out-of-pocket costs vary by plan. Our admissions team can verify benefits and review available options before admission.
Brixadi is an FDA-approved extended-release buprenorphine injection used to treat moderate to severe opioid use disorder. It comes in weekly and monthly formulations and helps reduce cravings, control withdrawal, and stabilize long-term recovery.
No. Brixadi does not contain naloxone. It is a buprenorphine-only extended-release injection. While some buprenorphine medications, like Suboxone®—combine buprenorphine with naloxone to discourage misuse, Brixadi is administered by a medical provider, so naloxone is not needed.
Brixadi is used for Medication-Assisted Treatment (MAT) to help individuals diagnosed with opioid use disorder. It supports recovery by:
Not exactly, both medications contain buprenorphine, but in different delivery systems.
Brixadi remains active for 7 days (weekly dose) or 28 days (monthly dose), depending on the formulation. Because it is an extended-release medication, buprenorphine levels remain steady in the bloodstream for the entire dosing period and may continue showing in urine tests for up to several weeks after the final injection.
Braeburn Inc. (2023, May 23). BRIXADI® (buprenorphine) extended-release injection: Full prescribing information. FDA. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/210136Orig1s000lbl.pdf
U.S. Food and Drug Administration. (2024, December 26). Information about medications for opioid use disorder (MOUD). https://www.fda.gov/drugs/information-drug-class/information-about-medications-opioid-use-disorder-moud
National Institute on Drug Abuse. (2025, March 20). Medications to treat opioid use disorder. https://nida.nih.gov/research-topics/medications-opioid-use-disorder
Substance Abuse and Mental Health Services Administration. (2025, August 25). Medications for substance use disorders: Treatment options. https://www.samhsa.gov/substance-use/treatment/options
Shulman, M., Brooner, R. K., et al. (2019). Buprenorphine treatment for opioid use disorder: A review of efficacy and safety. Journal of Addiction Medicine, 13(6), 472–482. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585403/
Dowell, D., Haegerich, T. M., & Chou, R. (2024). Medications for opioid use disorder can substantially reduce overdose deaths — United States, 2022. Morbidity and Mortality Weekly Report (MMWR), 73(25), 705–710. https://www.cdc.gov/mmwr/volumes/73/wr/mm7325a1.htm
Office of National Drug Control Policy / NIH. (2021). Treatment Improvement Protocol (TIP) 63: Medications for opioid use disorder. U.S. Government. https://library.samhsa.gov/product/TIP-63-Medications-for-Opioid-Use-Disorder-Full-Document/PEP21-02-01-002
Oesterle, T. S., et al. (2019). Medication-Assisted Treatment for Opioid Use Disorder: Evidence Review. Mayo Clinic Proceedings, 94(6), 1060–1075. https://www.mayoclinicproceedings.org/article/S0025-6196(19)30393-3/fulltext mayoclinicproceedings.org
